A. S. Kritchenkov, M. N. Kurasova, A. A. Godzishevskaya, E. S. Mitrofanova, A. R. Egorov, N. Z. Yagafarov, M. J. Ballesteros Meza, A. G. Tskhovrebov, A. A. Artemjev, E. V. Andrusenko, V. N. Khrustalev, “High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles”, Mendeleev Commun., 2021, Volume 31, Issue 4,Pages <nobr>504

This article is cited in 11 papers

Communications

High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

A. S. Kritchenkov^ab, M. N. Kurasova^a, A. A. Godzishevskaya^a, E. S. Mitrofanova^a, A. R. Egorov^a, N. Z. Yagafarov^ac, M. J. Ballesteros Meza^a, A. G. Tskhovrebov^a, A. A. Artemjev^a, E. V. Andrusenko^d, V. N. Khrustalev^ae

^a Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^b Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, Republic of Belarus
^c N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^d Department of Chemistry, Altay State University, Barnaul, Russian Federation
^e N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH₄. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin.

Keywords: chitosan, pyridoxal, nanoparticles, antibacterial activity, low toxicity.

Language: English

DOI: 10.1016/j.mencom.2021.07.022

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