E. V. Kuznetsova, K. T. Kalinin, N. G. Sedush, A. A. Nazarov, D. S. Volkov, S. N. Chvalun, “Structure and cytotoxicity of biodegradable poly(d,l-lactide-<i>co</i>-glycolide) nanoparticles loaded with oxaliplatin”, Mendeleev Commun., 2021, Volume 31, Issue 4,Pages <nobr>512

This article is cited in 15 papers

Communications

Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin

E. V. Kuznetsova^a, K. T. Kalinin^a, N. G. Sedush^a, A. A. Nazarov^b, D. S. Volkov^b, S. N. Chvalun^ac

^a National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
^b Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c N.S. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Spherical nanoparticles based on the biocompatible and biodegradable poly(d,l-lactide-co-glycolide) copolymer (90 : 10) loaded with oxaliplatin were produced by nanoprecipitation. Effect of the oxaliplatin loading on structure, size and morphology of the copolymer particles is considered. The nanoformulation of oxaliplatin demonstrates enhanced cytotoxicity and selectivity in vitro against several cancer cells compared with the free drug.

Language: English

DOI: 10.1016/j.mencom.2021.07.025

	*Supplementary materials:*
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