T. P. Trofimova, V. A. Tafeenko, A. S. Borodkov, A. N. Proshin, M. A. Orlova, “New copper complexes with <i>N-</i>(5,6-dihydro-4<i>H</i>-1,3-thiazin-2-yl)benzamide ligand”, Mendeleev Commun., 2021, Volume 31, Issue 4,Pages <nobr>552–554</nobr>

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Mendeleev Commun., 2021 Volume 31, Issue 4, Pages 552–554 (Mi mendc987)

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Communications

New copper complexes with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide ligand

T. P. Trofimova^a, V. A. Tafeenko^a, A. S. Borodkov^b, A. N. Proshin^c, M. A. Orlova^ad

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^d N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation

Abstract: Crystals of two copper complexes with N-(5,6-dihydro-4H- +1,3-thiazin-2-yl)benzamide were obtained and characterized by X-ray diffraction analysis. LETDI studies have shown that the composition of the complex is inhomogeneous, and the precipitated crystals can have different structures being of Cuii or Cui–Cuii types. The complexes are significantly more cytotoxic toward the leukemic Jurkat cell line than to healthy lymphocytes.

Language: English

DOI: 10.1016/j.mencom.2021.07.039

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