K. A. Novikov, A. A. Romanyukha, A. N. Gratchev, J. G. Kzhyshkowska, O. A. Melnichenko, “Mathematical model of cellular transport network self-organization and functioning”, Mat. Model., 2015, Volume 27, Number 3,Pages <nobr>49

This article is cited in 1 paper

Mathematical model of cellular transport network self-organization and functioning

K. A. Novikov^ab, A. A. Romanyukha^cad, A. N. Gratchev^ef, J. G. Kzhyshkowska^ef, O. A. Melnichenko^g

^a Lomonosov Moscow State University, Department of Computational Mathematics and Cybernetics
^b Federal Research Institute for Health Organization and Informatics
^c Institute of Numerical Mathematics Russian Academy of Sciences
^d Moscow Institute of Physics and Technology, Department of Problems of Physics and Power Engineering
^e Heidelberg University, Faculty of Medicine
^f Institute of Cancerogenesis, N. N. Blokhin Cancer Research Center, RAMS
^g Novartis Pharma LLC

Abstract: Contemporary cell investigation methods allowed molecular transport mechanisms of intracellular substances and cell components to be described. Analysis of completeness and consistency of existent data of transport network nature and its utilization is a problem of mathematical modeling. Self-organization of the cell transport network and transport of the cargo and organelles upon it are modeled in this work by the examples of mitotic spindle formation, retrograde axonal transport and lipid transport.

Keywords: cell, metabolism, transport network, vesicles, endosomes, self-organization, microtubules.

UDC: 519.711.2

Received: 16.01.2014