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Nanosystems: Physics, Chemistry, Mathematics, 2022 Volume 13, Issue 2, Pages 204–211 (Mi nano1101)

CHEMISTRY AND MATERIAL SCIENCE

Synthesis and analysis of cerium-containing carbon quantum dots for bioimaging in vitro

A. L. Popova, I. V. Savintsevaa, A. M. Ermakova, N. R. Popovaa, D. D. Kolmanovicha, N. N. Chukavinab, A. F. Stolyarova, A. B. Shcherbakovc, O. S. Ivanovad, V. K. Ivanovd

a Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 142290, Russia
b Moscow Region State University, 141014, Moscow, Russia
c Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine
d Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, 119991, Russia

Abstract: The latest biomedical approaches based on the use of nanomaterials possessing luminescent properties make it possible to effectively visualize cancer cells or tissues, thus expanding diagnostic capabilities of the current bioimaging techniques. In this paper, a new scheme is proposed for the synthesis of cerium-containing carbon quantum dots (Ce-Qdots) of ultra-small size, promising for biomaging. Ce-Qdots have a high degree of biocompatibility, as well as remarkable redox activity. Cytotoxicity analysis performed using 4 human cell cultures confirmed the high degree of Ce-Qdots biocompatibility. It was shown that Ce-Qdots in concentrations up to 200 $\mu$g/ml do not have a negative effect on the metabolic, proliferative, migration and clonogenic activity of cell cultures after 24, 48 and 72 hours of coincubation. Ce-Qdots can be considered as the basis of a new theranostic agent for bioimaging and targeted delivery of biologically active substances.

Keywords: carbon dots, quantum dots, ceria, bioimaging, cell uptake, viability, luminescence.

Received: 08.02.2022
Revised: 26.03.2022

Language: English

DOI: 10.17586/2220-8054-2022-13-2-204-211



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