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JOURNALS // Nanosystems: Physics, Chemistry, Mathematics // Archive

Nanosystems: Physics, Chemistry, Mathematics, 2019 Volume 10, Issue 2, Pages 184–189 (Mi nano431)

This article is cited in 3 papers

CHEMISTRY AND MATERIAL SCIENCE

Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation

A. E. Goldta, A. Yu. Polyakovb, T. A. Sorkinac, A. L. Dubovde, G. A. Davidovaf, I. I. Seleznevaf, Yu. V. Maximovg, I. A. Presnyakovd, N. Yu. Polyakovah, E. A. Goodilinedb, I. V. Perminovad

a Skolkovo Institute of Science and Technology, Moscow, Russia
b Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia
c Science & Technology Department, Management Company RUSNANO, LLC, Moscow, Russia
d Department of Materials Science, Lomonosov Moscow State University, Moscow 119991, Russia
e Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
f Institute of Theoretical & Experimental Biophysics of Russian Academy of Sciences, Pushchino 142290, Russia
g Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow 119991, Russia
h I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Abstract: Superparamagnetic iron oxide $\gamma$-Fe$_{2}$O$_{3}$ (maghemite) nanoparticles (SPION) encapsulated into water-soluble microspheres of rock salt were synthesized via a new aerosol spray pyrolysis procedure. Humic acids (HA) were employed to stabilize the aqueous suspensions of $\gamma$-Fe$_{2}$O$_{3}$ nanoparticles released upon dissolution of the NaCl matrix. The effect of HA on the surface charge of maghemite-based colloids was studied in pH range of 3–10. Humic polyanions compensate positive charges on a hydrated $\gamma$-Fe$_{2}$O$_{3}$ surface resulting in strongly negative $\zeta$-potential ($<$ -40 mV) of colloid even in acidic environment. In neutral and alkaline environment, $\zeta$-potential of maghemite-based colloid drops below -55 mV; thus, HA should effectively stabilize the nanoparticle colloid over the whole pH range studied. Meanwhile, bare maghemite SPION at pH 3–6 have $\zeta$-potential in the +20 mV to -20 mV range (isoelectric point at pH 4.35), which is insufficient for electrostatic stabilization of the suspensions. The absence of embryotoxicity of HA-stabilized nanoparticles was demonstrated.

Keywords: small superparamagnetic iron oxide nanoparticles (SPION), humic acids, magnetic fluids, colloidal properties, embryotoxicity, biomedicine.

PACS: 75.47.Lx, 82.70.Dd

Received: 20.01.2019
Revised: 31.01.2019

Language: English

DOI: 10.17586/2220-8054-2019-10-2-184-189



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