Effect of light exposure duration on the skin microcirculatory system by laser Doppler flowmetry in experiment

We studied the effect of long-term light exposure (model 18:6) on the functioning of regulatory mechanisms of the skin microcirculatory channel in the experiment. The study of microcirculation was performed using the method of laser Doppler flowmetry. It was found that prolonged light exposure causes impaired regulation of blood flow in the microcirculatory bed (reduction of amplitudes of endothelial, neurogenic and myogenic oscillations) and reduced tissue perfusion. The severity of hemodynamic disorders increases with increasing duration of light exposure. Decrease in perfusion and progression of violations of active factors regulating the processes of microcirculation indicate a negative effect of light exposure on tissue perfusion, which may serve as a risk factor for cardiovascular pathology.