T. A. Telegina, Yu. L. Vechtomova, M. S. Kritsky, A. S. Nizamutdinov, E. I. Madirov, D. A. Makarova, A. A. Buglak, “Photooxidation of tetrahydrobiopterin as the basis of vitiligo phototherapy”, Optics and Spectroscopy, 2022, Volume 130, Issue 5,Pages <nobr>761

5th Memorial Symposium "Molecular Photonics" dedicated to the memory of Academician A.N.Terenin, May 6, 2021 St. Petersburg, Russia
Biophotonics

Photooxidation of tetrahydrobiopterin as the basis of vitiligo phototherapy

T. A. Telegina^abc, Yu. L. Vechtomova^ab, M. S. Kritsky^a, A. S. Nizamutdinov^d, E. I. Madirov^cd, D. A. Makarova^d, A. A. Buglak^c

^a A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow
^b Federal Research Centre "Fundamentals of Biotechnology", Russian Academy of Sciences, 119071 Moscow, Russia
^c Saint Petersburg State University, 199034 St. Petersburg, Russia
^d Kazan Federal University, 420008 Kazan, Tatarstan, Russia

Abstract: The kinetics of photooxidation of tetrahydrobiopterin was investigated, the quantum yields of the formation of dihydropterin dimers were calculated when using a xenon lamp, a tunable UV laser and a UV LED as UV radiation sources. A comparative analysis of the effectiveness of these sources for the photooxidation process of tetrahydrobiopterin allowed us to conclude that the most effective for the purposes of vitiligo phototherapy are, apparently, UV LED sources with emission maxima in the region of 325 nm.

Keywords: vitiligo, tetrahydrobiopterin, melanin, oxidative stress, H$_2$O$_2$, UVB vitiligo phototherapy.

Received: 23.01.2022
Revised: 07.02.2022
Accepted: 10.02.2022

DOI: 10.21883/OS.2022.05.52432.14-22