Structural changes in the skin and muscle tissue of rats with a model of diabetes

Structural changes in the skin and skeletal muscles of rats with alloxan-induced diabetes were studied by scanning electron microscopy (SEM). Tissue samples were prepared for SEM using standard histological methods. The results of the study showed that diabetes causes a number of changes in the structure of the skin and muscles of the thigh, which was confirmed by histological examination. In particular, a decrease in the integrity of collagen fibrous structures was revealed. The severity of structural changes in skin and muscle tissues depended on the level of free glucose blood levels and the type of simulated diabetes.