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Optics and Spectroscopy, 2025 Volume 133, Issue 12, Pages 1321–1326 (Mi os2033)

Special Section "Biophotonics" in Memory of Vladimir Leonidovich Kuzmin

Application of high-resolution terahertz spectroscopy to study the chemical composition of thermal decomposition products of bladder cancer tissues

V. L. Vaksab, V. A. Anferteva, E. G. Domrachevaab, M. B. Chernyaevaab, V. A. Atduevcd, K. A. Atduevc, A. S. Chernyaevaa

a Institute for Physics of Microstructures, Russian Academy of Sciences, Nizhnii Novgorod
b National Research Lobachevsky State University of Nizhny Novgorod
c Privolzhsky District Medical Centre of the Federal Medical and Biological Agency of Russia, Nizhny Novgorod
d Privolzhsky Research Medical University, Nizhny Novgorod

Abstract: Due to the need to detect oncological diseases at an earlier stage, when timely surgical or therapeutic treatment increases the likelihood of patient survival, it is urgent to search for and develop effective diagnostic and therapeutic strategies. Approaches based on metabolomics have the potential to identify sets of metabolite markers of cancer, which is important for early cancer recognition. One of the types of cancer that are difficult to detect in the early stages in modern conditions is urothelial cancer, for which the metabolic approach is promising in the early stages. The work is devoted to the study of the chemical composition of thermal decomposition products of primary metabolites for bladder tumor tissues, conducted for the first time using high-resolution THz spectroscopy methods.

Keywords: bladder cancer, biological tissue, thermal decomposition products, metabolites, high-resolution THz spectroscopy.

Received: 31.10.2025
Revised: 17.11.2025
Accepted: 25.11.2025

DOI: 10.61011/OS.2025.12.62507.47-25



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© Steklov Math. Inst. of RAS, 2026