M. M. Nazarov, O. P. Cherkasova, E. N. Lazareva, A. B. Bucharskaya, N. A. Navolokin, V. V. Tuchin, A. P. Shkurinov, “A complex study of the peculiarities of blood serum absorption of rats with experimental liver cancer”, Optics and Spectroscopy, 2019, Volume 126, Issue 6,Pages <nobr>799

This article is cited in 15 papers

The 22nd Annual Conference Saratov Fall Meeting 2018 (SFM'18): VI International Symposium ''Optics and Biophotonics'' and XXII International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics
Biophotonics

A complex study of the peculiarities of blood serum absorption of rats with experimental liver cancer

M. M. Nazarov^a, O. P. Cherkasova^bcd, E. N. Lazareva^be, A. B. Bucharskaya^f, N. A. Navolokin^f, V. V. Tuchin^ebg, A. P. Shkurinov^hi

^a National Research Centre "Kurchatov Institute", Moscow
^b Tomsk State University
^c Novosibirsk State Technical University
^d Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk
^e Saratov State University
^f Saratov State Medical University named after V. I. Razumovsky
^g Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov
^h Lomonosov Moscow State University
ⁱ Institute for Problems of Laser and Information Technologies of the Russian Academy of Sciences, Branch of Federal Scientific Research Center Crystallography and Photonics, Shatura, Russia

Abstract: The THz-TDS in the frequency range of 0.05–1.0 THz has been used to study the blood serum of rats in dynamics of experimental liver cancer. THz transmission spectra of samples from healthy rats and for 14 and 28 days after implantation of tumor cells have a similar shape, but differ in amplitude. The protein content decreases for the case of 28th day of the implantation, as it have been measured by biochemical analysis. The observed changes in the THz response are explained by a decrease in the number of protein molecules and water bounded with it. Those results correlate with decrease in the refractive index in the visible and near IR range from 480 to 1550 nm, measured with a multiwave refractometer.

Received: 17.12.2018
Revised: 13.02.2019
Accepted: 26.02.2019

DOI: 10.21883/OS.2019.06.47775.53-19