M. V. Kruchinina, Ya. I. Prudnikova, A. A. Gromov, V. M. Generalov, K. V. Generalov, V. N. Kruchinin, E. V. Kruchinina, G. V. Shuvalov, I. N. Yakovina, N. A. Bannova, O. V. Minin, I. V. Minin, “New opportunities for colorectal cancer diagnostics using an optical cell detection system based on dielectrophoresis”, Optics and Spectroscopy, 2019, Volume 126, Issue 5,Pages <nobr>650

This article is cited in 5 papers

The 22nd Annual Conference Saratov Fall Meeting 2018 (SFM'18): VI International Symposium ''Optics and Biophotonics'' and XXII International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics
Biophotonics

New opportunities for colorectal cancer diagnostics using an optical cell detection system based on dielectrophoresis

M. V. Kruchinina^ab, Ya. I. Prudnikova^a, A. A. Gromov^a, V. M. Generalov^c, K. V. Generalov^c, V. N. Kruchinin^d, E. V. Kruchinina^b, G. V. Shuvalov^e, I. N. Yakovina^f, N. A. Bannova^f, O. V. Minin^g, I. V. Minin^e

^a Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
^b Novosibirsk State Medical University, Novosibirsk
^c State Research Center of Virology and Biotechnology Vector, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Novosibirsk, Koltsovo, Russia
^d Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
^e Federal State Unitary Enterprise "Siberian Scientific Research Institute of Metrology", Novosibirsk
^f Novosibirsk State Technical University
^g Tomsk State University

Abstract: The possibilities of using electrical and viscoelastic parameters of erythrocytes in patients with colorectal cancer (CRC) of different stages were demonstrated using optical cell detection system based on the dielectrophoresis method. The deformation amplitude, portion of deformed cells, generalized viscosity, rigidity, equilibrium frequency position, and electrical conductivity were the most significant parameters for determining patients with CRC, as well as early and late stages, included in the created model of a riskometer for the disease diagnosis. The created diagnostic “panels” with a high diagnostic accuracy, sensitivity, and specificity allowed to one determine patients with CRC (specificity 0.91, sensitivity 0.96), as well as early and late stages of the disease (specificity 0.64, sensitivity 0.86).

Received: 24.12.2018
Revised: 28.01.2019
Accepted: 31.01.2019

DOI: 10.21883/OS.2019.05.47666.15-19