E. V. Kulakova, A. M. Spitsina, N. G. Orlova, A. I. Dergilev, A. V. Svichkarev, N. S. Safronova, I. G. Chernykh, Yu. L. Orlov, “Supercomputer analysis of genomics and transcriptomics data revealed by high-throughput DNA sequencing”, Program Systems: Theory and Applications, 2015, Volume 6, Issue 2,Pages <nobr>129

This article is cited in 2 papers

Hardware, software and distributed supercomputer systems

Supercomputer analysis of genomics and transcriptomics data revealed by high-throughput DNA sequencing

E. V. Kulakova^a, A. M. Spitsina^a, N. G. Orlova^a, A. I. Dergilev^a, A. V. Svichkarev^a, N. S. Safronova^a, I. G. Chernykh^b, Yu. L. Orlov^b

^a Novosibirsk State University
^b Institute of Cytology and Genetics SB RAS

Abstract: Growing volumes of genomic data on transcription factor binding site location, chromosome contacts and the genome features annotations basedon modern sequencing technologies need development of new software and algorithms for processing and analysis of such data. The supercomputing allows to study problems of transcription regulation at qualitatively new level. We consider problems of genome sequencing based on ChIP-seq, ChIA-PET and Hi-C technologies. We present computer programs to solve these tasks and discuss future development. (In Russian).

Key words and phrases: bioinformatics, DNA sequencing, immunoprecipitation, chromosome contacts, gene expression regulation, databases.

UDC: 004.031.2

Received: 14.05.2015
Accepted: 25.05.2015