RUS  ENG
Full version
JOURNALS // Problemy Upravleniya // Archive

Probl. Upr., 2011 Issue 3, Pages 56–63 (Mi pu653)

This article is cited in 2 papers

Control of medicobiologic systems

Control of chemotherapy on ferromagnetic nanoparticles

N. A. Babushkina

Institute of Control Sciences, Russian Academy of Sciences, Moscow

Abstract: The paper presents the mathematical model of chemotherapy on ferromagnetic nanoparticles. The model describes the process of tumor cells death when the method of magnetic localization of the antitumoral preparation inside the tumor is applied. This method allows destroying the oxygenated tumor cells located near the blood vessels as well as hypoxic tumor cells located on the tumor periphery. The method allows to increase the efficiency of chemotherapy to a considerable extent. One of the control parameters of this method is the intensity of the external electromagnetic field at the moment of medicine introduction. This intensity defines the efficient doze size and the period of desorption of the preparation on ferromagnetic nanoparticles inside the tumor.

Keywords: mathematical model, chemotherapy, tumor cells, electromagnetic field intensity, effective doze size, preparation desorption.

UDC: 616-006+519.7



© Steklov Math. Inst. of RAS, 2025