Yu. S. Samsonova, A. V. Priezzhev, A. E. Lugovtsov, G. P. Petrova, V. V. Gibizova, Y.-S. Ye, T.-H. Su, E. V. Perevedentseva, C.-L. Cheng, “Investigation of interaction of albumin molecules with diamond nanoparticles in aqueous solutions by dynamic light scattering”, Kvantovaya Elektronika, 2012, Volume 42, Number 6,Pages <nobr>484

This article is cited in 6 papers

Biophotonics

Investigation of interaction of albumin molecules with diamond nanoparticles in aqueous solutions by dynamic light scattering

Yu. S. Samsonova^a, A. V. Priezzhev^ab, A. E. Lugovtsov^b, G. P. Petrova^a, V. V. Gibizova^a, Y.-S. Ye^c, T.-H. Su^c, E. V. Perevedentseva^dc, C.-L. Cheng^c

^a Lomonosov Moscow State University, Faculty of Physics
^b International Laser Center of Moscow State University
^c National Dong Hwa University, Taiwan
^d P. N. Lebedev Physical Institute, Russian Academy of Sciences, Moscow

Abstract: The method of dynamic light scattering has been used to study the interaction of albumin molecules with diamond nanoparticles in aqueous solutions. It is shown that due to adsorption of albumin on diamond nanoparticles, larger size particles are formed. We have obtained the concentration dependences of the average hydrodynamic radius of these particles. It is found that the carboxylation of the surface of diamond nanoparticles and their pre-coating by albumin leads to a decrease in the adsorption of protein molecules on the surface of nanoparticles and to a decrease in their average hydrodynamic radius. We have also shown that in the range of concentrations of diamond nanoparticles 2 — 10 μg mL^-1, their interaction with albumin molecules at different pH has a different character.

Keywords: diamond nanoparticles, serum albumin, dynamic light scattering, photon correlation spectroscopy, adsorption, hydrodynamic radius, isoelectric point.

PACS: 87.64.Cc, 87.15.N-, 78.67.Bf, 81.05.ug

Received: 15.05.2012