M. V. Korchenova, E. S. Tuchina, V. Y. Shvayko, A. G. Gulkhandanyan, A. A. Zakoyan, R. K. Ghazaryan, G. V. Gulkhandanyan, B. M. Dzhagarov, V. V. Tuchin, “Photodynamic effect of radiation with the wavelength 405 nm on the cells of microorganisms sensitised by metalloporphyrin compounds”, Kvantovaya Elektronika, 2016, Volume 46, Number 6,Pages <nobr>521

This article is cited in 6 papers

Laser biophotonics

Photodynamic effect of radiation with the wavelength 405 nm on the cells of microorganisms sensitised by metalloporphyrin compounds

M. V. Korchenova^a, E. S. Tuchina^a, V. Y. Shvayko^a, A. G. Gulkhandanyan^b, A. A. Zakoyan^b, R. K. Ghazaryan^c, G. V. Gulkhandanyan^b, B. M. Dzhagarov^d, V. V. Tuchin^efg

^a Saratov State University
^b Institute of Biochemistry, National Academy of Sciences of Armenia, Armenia
^c Yerevan State Medical University after Mkhitar Heratsi
^d B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, Minsk
^e Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov
^f Tomsk State University
^g OBP Research-Educational Institute of Optics and Biophotonics, Saratov State University

Abstract: We have studied the photodynamic activity of photosensitisers based on metalloporphyrins. New metalloporphyrin compounds are synthesised and characterised, the quantum yields of the singlet oxygen formation are analysed. It is shown that when the photodynamic effect is implemented using the metalloporphyrins with Zn ions and butyl radical in the 3rd and 4th positions of the pyridine ring, the number of opportunistic bacteria, such as Staphylococcus aureus (antibiotic-sensitives and antibiotic-resistant strains), Staphylococcus simulans and Escherichia coli is efficiently reduced by 90% – 99%.

Keywords: photodynamic therapy, radiation with the wavelength 405 nm, microorganisms, S. aureus, S. simulans, E. coli, metalloporphyrins.

Received: 21.04.2016