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JOURNALS // Uspekhi Khimii // Archive

Usp. Khim., 1995 Volume 64, Issue 8, Pages 850–858 (Mi rcr1252)

This article is cited in 2 papers

Synthesis of nucleoside 5'-triphosphates labelled with radioactive phosphorus isotopes

Yu. S. Skoblova, A. E. Korolevb, R. N. Maslovac

a State Scientific Centre of Russian Federation, Institute for Physics and Power Engineering, Obninsk, Kaluga region
b Isotopchim S.A.R.L. B.P., France
c Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow

Abstract: The review presents an analysis of the chemical chemicoenzymic, and enzymic methods of synthesis of nucleoside 5'-triphosphates labelled with phosphorus isotopes ( 32P and 33P) in the α- and γ-positions. The major part of the review is devoted to enzymic methods of synthesis, because they have undoubted advantages. The enzymatic reactions are described in detail, the specificity and availability of the enzymes are considered, and data on the radiation stability of certain enzymes are presented. The bibliography includes 29 references.

UDC: 547.963

Received: 03.03.1995

DOI: 10.1070/RC1995v064n08ABEH000176


 English version:
Russian Chemical Reviews, 1995, 64:8, 799–807

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