Multicomponent reactions of isocyanides in the synthesis of heterocycles

The latest achievements in the field of isocyanide-based multicomponent reactions for the synthesis of heterocycles are generalized. The attention is focused on the intramolecular Ugi reactions of oxocarboxylic acids and the reactions of diaza nucleophiles developed in recent years. The data on the biological activities of the products are presented and the advantages of this method as a convenient and effective tool of medicinal chemistry are demonstrated.