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JOURNALS // Uspekhi Khimii // Archive

Usp. Khim., 1970 Volume 39, Issue 4, Pages 646–661 (Mi rcr2349)

This article is cited in 2 papers

Steroids with a Heteroatom in the Nucleus or the Side Chain of the Molecule

G. I. Zhungietua, G. N. Dorofeenkob, B. M. Savinc

a Institute of Chemistry, Academy of Sciences of the Moldavian SSR, Kishinev
b Rostov State University
c Kharkov Factory Endocrine Agents

Abstract: Methods for the synthesis of steroid compounds with N, O, and S atoms in the molecular side chain and steroid compounds containing an oxygen atom in the main steroid nucleus, obtained by the reaction of unsaturated steroids with ozone, are discussed. Methods for the preparation of steroids containing a nitrogen atom in the nucleus, synthesised by the reaction with ozone of unsaturated αβ-steroid ketones with subsequent heterocyclisation of the reaction products, are analysed. Methods are described for the total synthesis of steroid heteroanalogues from precursors of comparatively simple structure. Data are presented on the biological activity of the compounds. The bibliography comprises 79 references.

UDC: 547.92

DOI: 10.1070/RC1970v039n04ABEH001963


 English version:
Russian Chemical Reviews, 1970, 39:4, 301–307

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