Abstract:
Methods for the synthesis of steroid compounds with N, O, and S atoms in the molecular side chain and steroid compounds containing an oxygen atom in the main steroid nucleus, obtained by the reaction of unsaturated steroids with ozone, are discussed. Methods for the preparation of steroids containing a nitrogen atom in the nucleus, synthesised by the reaction with ozone of unsaturated αβ-steroid ketones with subsequent heterocyclisation of the reaction products, are analysed. Methods are described for the total synthesis of steroid heteroanalogues from precursors of comparatively simple structure. Data are presented on the biological activity of the compounds. The bibliography comprises 79 references.