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JOURNALS // Uspekhi Khimii // Archive

Usp. Khim., 2008 Volume 77, Issue 11, Pages 1036–1052 (Mi rcr253)

This article is cited in 8 papers

Low-molecular-weight inhibitors of NF-κB signalling pathways

N. G. Dolinnayaa, E. A. Kubarevab, E. V. Kazanovaa, N. A. Zigangirovac, B. S. Naroditskyc, A. L. Gintsburgc, T. S. Oretskayaab

a Lomonosov Moscow State University, Faculty of Chemistry
b Lomonosov Moscow State University, Belozersky Research Institute of Physico-Chemical Biology
c N. F. Gamalei Research Institute for Epidemiology and Microbiology Russian Academy of Medical Sciences

Abstract: The nuclear factor κB (NF-κB) is a transcription factor involved in inducible expression of cellular genes playing a key role in cardiovascular pathologies, carcinogenesis, inflammatory and viral diseases. The review describes the stimuli and processes inducing NF-κB activation and the components of a signalling cascade that could constitute targets for NF-κB inhibition. The molecular action and properties of various low-molecular weight inhibitors aiming to prevent NF-κB activity are summarised.

Received: 04.06.2008

DOI: 10.1070/RC2008v077n11ABEH003881


 English version:
Russian Chemical Reviews, 2008, 77:11, 967–981

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