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JOURNALS // Uspekhi Khimii // Archive

Usp. Khim., 2015 Volume 84, Issue 1, Pages 43–60 (Mi rcr4028)

This article is cited in 18 papers

New approaches to targeted drug delivery to tumour cells

E. S. Severin

Russian Research Center of Molecular Diagnostics and Therapy, Moscow, Russian Federation

Abstract: Basic approaches to the design of targeted drugs for the treatment of human malignant tumours have been considered. The stages of the development of these approaches have been described in detail and theoretically substantiated, and basic experimental results have been reported. Considerable attention is paid to the general characteristic of nanopharmacological drugs and to the description of mechanisms of cellular interactions with nanodrugs. The potentialities and limitations of application of nanodrugs for cancer therapy and treatment of other diseases have been considered. The use of nanodrugs conjugated with vector molecules seems to be the most promising trend of targeted therapy of malignant tumours.
The bibliography includes 122 references.

Received: 20.05.2014

DOI: 10.1070/RCR4468


 English version:
Russian Chemical Reviews, 2015, 84:1, 43–60

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