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Usp. Khim., 2023 Volume 92, Issue 3, Pages 1–17 (Mi rcr4417)

Synthesis of α-amino carbonyl compounds: a brief review

A. Mukherjeea, S. Mahatob, D. S. Kopchukac, S. Santraa, G. V. Zyryanovac, A. Majeeb, O. N. Chupakhinab

a Chemical Technological Institute, Ural Federal University named after the First President of Russia B. N. Yeltsin, Ekaterinburg
b Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, India
c I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg

Abstract: α-Amino carbonyl compounds are an important class of nitrogen-containing substances. This review highlights their synthesis using various strategies and considers mechanisms of the processes. The strategies are classified into subcategories based on the type of starting materials, chemical reactions and synthetic methods in use. In the literature survey, different types of reactions are discussed like oxidation, reduction, addition, coupling, C–H amination, oxidative cleavage and rearrangement, amidation, multicomponent cascade reaction, etc., for the synthesis of these compounds.
Bibliography — 100 references.

Keywords: α-amino carbonyls, α-amino ketones, natural products, synthesis, coupling reactions, reaction mechanism.

Received: 20.12.2022

DOI: 10.57634/RCR5046


 English version:
Russian Chemical Reviews, 2023, 92:3, 1–17

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© Steklov Math. Inst. of RAS, 2024