Small molecules against viruses causing hemorrhagic fevers in Russia

This review is devoted to small molecules (compounds with molecular weights of up to 800–900 Da) that show activity against viruses causing hemorrhagic fevers. Despite the wide occurrence of hemorrhagic fevers, effective medications for their prevention and treatment are virtually absent. Currently, the search for a new drug to fight these viruses is still a relevant task, since the synthetic nucleoside ribavirin used in clinical practice is not sufficiently effective. The review presents compounds that have antiviral action against the causative agents or alleviate symptoms of three acute infectious diseases occurring in Russia: Omsk hemorrhagic fever, Crimean-Congo hemorrhagic fever, and hemorrhagic fever with renal syndrome. The structures and activity parameters (half maximal inhibitory concentration) of the compounds are given and hypothesized mechanisms of their action are considered. The data published during the whole period of studies of these diseases are summarized.
The bibliography includes 160 references.