L. G. Dezhenkova, V. B. Tsvetkov, A. A. Shtil, “Inhibitors of topoisomerases I and II: chemical structure, mechanisms of action and the role in cancer chemotherapy”, Usp. Khim., 2014, Volume 83, Issue 1,Pages <nobr>82

This article is cited in 31 papers

Inhibitors of topoisomerases I and II: chemical structure, mechanisms of action and the role in cancer chemotherapy

L. G. Dezhenkova^a, V. B. Tsvetkov^bc, A. A. Shtil^d

^a G. F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow
^b A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow
^c Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
^d N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Abstract: The modern literature data on topoisomerase I and II inhibitors as potential antitumour drugs are integrated and analyzed. The functions and mechanisms of action of topoisomerases and the molecular mechanisms of interaction of low molecular weight compounds with topoisomerases are considered. The topoisomerase inhibitors of a variety of chemical classes are described systematically. The tests used to elucidate the topoisomerase inhibition and the potential of computer-assisted modelling for the rational design of new drugs for cancer chemotherapy are presented.
Bibliography — 127 references.

Received: 05.12.2012

DOI: 10.1070/RC2014v083n01ABEH004363