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JOURNALS // Sibirskii Zhurnal Vychislitel'noi Matematiki // Archive

Sib. Zh. Vychisl. Mat., 2025 Volume 28, Number 1, Pages 37–46 (Mi sjvm892)

Mathematical and numerical modeling of the pluripotency gene network dynamics

V. P. Golubyatnikov, E. A. Tatarinova

Novosibirsk State University

Abstract: We consider nonlinear dynamical systems as a model of interaction of components of a gene network which regulates early stages of an embryonic stem cells state. A parametric analysis of these dynamical systems is performed in order to describe the (non)uniqueness and stability of their equilibriums. We have obtained a criterion of existence of periodic trajectories near these points and localized these oscillations on the phase portraits of dynamical systems which describe these processes. A special software for cloud numerical experiments with these systems has been elaborated.

Key words: gene networks, positive and negative feedbacks, nonlinear dynamical systems, equilibrium points, stability.

UDC: 517.938

Received: 07.05.2024
Revised: 16.05.2024
Accepted: 20.09.2024

DOI: 10.15372/SJNM20250103



© Steklov Math. Inst. of RAS, 2025