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JOURNALS // Teplofizika vysokikh temperatur // Archive

TVT, 2019 Volume 57, Issue 5, Pages 764–768 (Mi tvt11087)

This article is cited in 4 papers

Heat and Mass Transfer and Physical Gasdynamics

Production of lidocaine nanoforms via the rapid extension of a supercritical solution into water medium

I. V. Kuznetsova, I. I. Gil'mutdinov, I. M. Gil'mutdinov, A. N. Sabirzyanov

Kazan National Research Technological University

Abstract: The pharmaceutical substances of a group of local anesthetics, in particular, the drug lidocaine, are the object of the study. The influence of the thermodynamic parameters of the state on the process of lidocaine dispersion via the rapid expansion of a supercritical solution in an aqueous medium (RESAS) is studied in this work. The experiments were carried out at saturation temperatures of $40$ and $60^{\circ}$C, a temperature of the expansion device of $40^{\circ}$C, and a system pressure of $15$$35$ MPa. The structure of the obtained particles was analyzed with a D8 ADVANCE diffractometer (before and after grinding). The melting points of the initial and processed lidocaine substance were determined.

UDC: 533.1, 536.75

Received: 09.07.2018
Revised: 23.01.2019
Accepted: 27.03.2019

DOI: 10.1134/S0040364419040136


 English version:
High Temperature, 2019, 57:5, 726–730

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