On identification of morbidity parameters in heterogeneous model: cases of complete and incomplete information

We suggest a methodology to estimate morbidity parameters in a three-state model, which includes the heterogeneity factor modeled with a gamma-distributed random variable. Models with complete and incomplete information are considered and various methods of risk estimation are discussed. We give estimates of morbidity radiation risks in four classes of diseases based on data from the Russian National Radiation Epidemiological Registry. The methodology can be used during the development of radiation protection systems.