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JOURNALS // Proceedings of the Yerevan State University, series Physical and Mathematical Sciences // Archive

Proceedings of the YSU, Physical and Mathematical Sciences, 2013 Issue 2, Pages 50–57 (Mi uzeru114)

Physics

Adsorption of short ligands on DNA with modification of adsorption center structure

V. B. Arakelyana, S. V. Harutyunyanb, V. K. Andriasyanc

a Yerevan State University
b Yerevan State Medical University after Mkhitar Heratsi
c University of Zurich

Abstract: The reversible adsorption of short ligands on DNA at arbitrary filling has been theoretically investigated, the kinetics of adsorption of ligands on DNA being described in a self-consistent way with the modified structure of an adsorbing center. The case when one adsorbed ligand occupied two adsorption centers on DNA was considered. It was shown that an allowance for the modification of the potential well of the adsorbing center led to the possibility of realizing various regimes of adsorption.

Keywords: adsorbing center, bifurcation, potential well, bistable adsorption regime.

Received: 19.04.2013
Accepted: 06.05.2013

Language: English



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