The conductivity of the monolayer of complexes of DNA with quantum dots in the presence of intercalating ligands

Factors that influence both the thermodynamics of hybridization and the conductivity of the sensitive layer of the DNA-chip are analyzed. The noncompetitive DNA hybridization and conductivity in the presence of non-charged ligands have been investigated and the comparison is made with the ligand-free case. It has been shown that the intercalating ligands enhance the sensitivity of the DNA chips as compared with the ligand-free case at the high enough concentration of ligands.