Effect of membrane depolarisation of suprachiasmatic nucleus neurons on spike activity in vitro

The properties of spike activity of neurons of the suprachiasmatic nucleus during their membrane depolarisation in vitro are investigated on rat hypothalamic slices. Depolarisation of membrane caused an increase in activity of cells and a decrease in entropy log interspike interval distribution were used as a measure of spikes irregularity generation. Possible mechanisms of the effects are discussed.