I. S. Kontsevaya, V. V. Nikolaevskyy, O. N. Makurina, “Genetic polymorphism of genes associated with virulence in <i>Mycobacterium tuberculosis</i> strains from Samara region”, Vestnik Samarskogo Gosudarstvennogo Universiteta. Estestvenno-Nauchnaya Seriya, 2014, Issue 3(114),Pages <nobr>178

Biology

Genetic polymorphism of genes associated with virulence in Mycobacterium tuberculosis strains from Samara region

I. S. Kontsevaya^a, V. V. Nikolaevskyy^b, O. N. Makurina^a

^a Samara State University, Samara, 443011, Russian Federation
^b Queen Mary's College,University of London, London E1 2AT

Abstract: The prevalence of polymorphisms in Mycobacterium tuberculosis genes associated with virulence as well as its associations with genetic groups, clusters of strains and drug susceptibility was investigated in the article. The associations between polymorphisms in plcA gene and some LAM family clusters, dosT and pks15/1 genes and Beijing family and lipR gene and the majority of Ghana, Cameroon, Uganda and S clusters were found. Detected interrelation between studied polymorphisms and drug susceptibility is of mediated character.

Keywords: tuberculosis, molecular epidemiology, genotyping, virulence, drug susceptibility.

UDC: 575.224.2

Received: 12.02.2014
Revised: 12.02.2014