Role of polymorphic gene variants SOD2, GSTT1, GSTM1 and GSTP1 in the development of breast cancer of women of chechen population

In the study, we investigated the role of polymorphic variants of genes of antioxidant protection SOD2 T/C (Ala16Val), GSTP1 A/G (Ile105Val), GSTM1 and GSTT1 Ins/Del in the development of malignancies (External testing) chest 564 women (208 women diagnosed with breast cancer (BC), 356 control group) of the Chechen population. For the studied populations have an increased frequency of polymorphisms Ala16Val, associated with the formation of malignant tumors, including breast External testing, but the differences are statistically insignificant character. The results showed no association between the presence of polymorphic variants SOD2 Ala16Val (T/C), GSTP1 (A/G), as well as deletions of genes GSTM1 and GSTT1 and the development of breast cancer in women of Chechen populations of cancer.