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JOURNALS // Vestnik Yuzhno-Ural'skogo Universiteta. Seriya Matematicheskoe Modelirovanie i Programmirovanie // Archive

Vestnik YuUrGU. Ser. Mat. Model. Progr., 2017 Volume 10, Issue 2, Pages 98–106 (Mi vyuru375)

Programming & Computer Software

A difference scheme for solving the equations of tumor growth subject to the restricted flow of motile cells

L. S. Isachenko, A. I. Lobanov

Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russian Federation

Abstract: The article investigates one-dimensional mathematical model of tumor growth represented by a system of quasi-linear parabolic equations. We assume certain restrictions on the full flow of the motile tumor cells, leading to the possible degeneration of the system into a hyperbolic type and emergence of discontinuous (weak) solution. To find weak solution we consider tumor growth as the emergence of a new phase. Thus we have a generalized (nonlinear) Stefan problem. The authors propose and implement a difference scheme with the explicit statement of the phase-change moving boundary to solve the problem. It is shown that this approach allows to describe different regimes of tumor growth.

Keywords: difference scheme; substrate taxis; the problem with movable boundary; break allocation.

UDC: 519.63

MSC: 65N06

Received: 30.06.2016

DOI: 10.14529/mmp170208



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