PdCu/Al2O3 catalyst for Sonogashira cross-coupling: effect of a Pd/Cu ratio on the catalytic performance

The catalytic performance of 3 wt% Pd–Cu/Al₂O₃ containing bimetallic alloy Pd–Cu nanoparticles strongly depends on the Pd/Cu ratio in the cross-coupling of phenylacetylene with phenyl iodide, and a maximum activity is attained at Pd/Cu=1:2.