M. G. Kasparavichius, D. I. Weber, A. S. Bunev, A. V. Sapegin, “Novel 2-amino-substituted (thio)morpholine-3,5-diones: synthesis and cytotoxicity studies”, Mendeleev Commun., 34:2 (2024), 262

Communications

Novel 2-amino-substituted (thio)morpholine-3,5-diones: synthesis and cytotoxicity studies

M. G. Kasparavichius^a, D. I. Weber^a, A. S. Bunev^ab, A. V. Sapegin^a

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b Medicinal Chemistry Centre, Togliatti State University, Togliatti, Russian Federation

Аннотация: The present study explores the synthesis of new potential Cereblon ligands, 2-amino derivatives of (thio)morpholine-3,5-diones. The resulting compounds demonstrate notable cytotoxic effects in tests conducted in vitro on myeloma cell lines, highlighting the potential of these compounds as molecular glues.

Ключевые слова: thiomorpholine-3,5-dione, morpholine-3,5-dione, amines, halogenation, nucleophilic substitution reaction, cytotoxicity studies, immunomodulatory drugs, Cereblon.

Язык публикации: английский

DOI: 10.1016/j.mencom.2024.02.032

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