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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2020, том 30, выпуск 1, страницы 15–17 (Mi mendc1086)

Эта публикация цитируется в 16 статьях

Communications

On water noncatalytic tandem Knoevenagel–Michael reaction of aldehydes, N,N’-dimethylbarbituric acid and cyclohexane-1,3-diones

M. N. Elinsona, A. N. Vereshchagina, Yu. E. Anisinaa, N. A. Leonovaab, M. P. Egorova

a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
b D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation


Аннотация: Heating aldehydes, N,N’-dimethylbarbituric acid and cyclohexane-1,3-diones in water results in fast formation of Knoevenagel–Michael adducts in 82–98% yields. This multicomponent process opens facile, efficient and environmentally benign way to the new functionalized [(2-hydroxy-6-oxocyclohex-1-en-1-yl)(aryl)methyl]pyrimidine-2,4(1H,3H)-diones bearing both barbituric acid and cyclohexane-1,3-dionemoieties separated by arylmethylene spacer, which are promising compounds for biomedical applications including analeptics, anti-AIDS and anticancer remedies.

Язык публикации: английский

DOI: 10.1016/j.mencom.2020.01.005



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