N. S. Kuzmina, V. F. Otvagin, L. V. Krylova, A. V. Nyuchev, Yu. V. Romanenko, O. I. Koifman, I. V. Balalaeva, A. Yu. Fedorov, “Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates”, Mendeleev Commun., 30:2 (2020), 159

Эта публикация цитируется в 13 статьях

Communications

Synthesis and antiproliferative activity of new chlorin e₆ glycoconjugates

N. S. Kuzmina^a, V. F. Otvagin^a, L. V. Krylova^a, A. V. Nyuchev^a, Yu. V. Romanenko^b, O. I. Koifman^b, I. V. Balalaeva^a, A. Yu. Fedorov^a

^a N.I. Lobachevsky State University of Nizhni Novgorod, Nizhni Novgorod, Russian Federation
^b Research Institute of Macroheterocycles, Ivanovo State University of Chemistry and Technology, Ivanovo, Russian Federation

Аннотация: New water soluble conjugates of chlorin e₆ derivative–zinc complex with β-d-galactose or β-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC_50(dark)/IC_50(light) ratio of ∼50.

Ключевые слова: chlorin e₆, glycoconjugate, water soluble, A431 cells, photodynamic therapy.

Язык публикации: английский

DOI: 10.1016/j.mencom.2020.03.009

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