L. A. Sviridova, P. S. Protopopova, M. G. Akimov, M. S. Dudina, E. K. Melnikova, K. A. Kochetkov, “Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles”, Mendeleev Commun., 30:3 (2020), 347

Эта публикация цитируется в 7 статьях

Communications

Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles

L. A. Sviridova^a, P. S. Protopopova^b, M. G. Akimov^c, M. S. Dudina^c, E. K. Melnikova^ab, K. A. Kochetkov^bd

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^c M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^d D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation

Аннотация: Boron trifluoride-catalyzed amidoalkylation of indole derivatives with 5-hydroxy-1-phenylimidozolidin-2-one affords new biheterocycles with a direct C–C bond. Among them, 3- or 2-(2-oxoimidazolidin-5-yl)indoles manifest antiinflammatory activity with relatively low toxicity.

Ключевые слова: amidoalkylation, biheterocycles, 3- or 2-(2-oxoimidazolidin-5-yl)indoles, anti-inflammatory activity, indoles, imidazolylindoles.

Язык публикации: английский

DOI: 10.1016/j.mencom.2020.05.029

	*Дополнительные материалы:*
		Supplementary_data_1.pdf	1.4 Mb