A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor

The Ni(acac)₂-catalyzed 1,2,4-triazole formation from cyanamides and carbohydrazides was extended onto N-(4,6-dimethylpyrimidin-2-yl)cyanamide and glycine hydrazides. The obtained N-(5-aminomethyl-4H-1,2,4-triazol-3-yl)-4,6-dimethylpyrimidin-2-amines may be attractive for the estimation of their biological activity.