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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2020, том 30, выпуск 6, страницы 747–749 (Mi mendc1312)

Эта публикация цитируется в 4 статьях

Communications

Microflow synthesis of fluorescent markers based on 1,8-naphthalimide for polylactide nanoparticles and bioimaging

M. S. Oshchepkova, A. S. Semyonkina, A. O. Menkova, P. A. Melnikovb, M. P. Valikhovb, I. N. Solovievaa, S. V. Tkachenkoa, J. A. Malinowskayab

a D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
b V.P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Moscow, Russian Federation


Аннотация: Two strategies for the synthesis of the new fluorescent markers based on 1,8-naphthalimide under classical conditions (in a flask) and in a microflow reactor are compared and contrasted. The microflow method provides higher purity of products, better productivity and production time. The resulting markers were used to obtain fluorescently labeled polylactide-based nanoparticles that can be used to study the distribution of polylactide nanoparticles as drug delivery vehicles within tissues and living organisms.

Ключевые слова: microfluidic synthesis, fluorescent markers, polylactide, 1,8-naphthalimide, bioimaging.

Язык публикации: английский

DOI: 10.1016/j.mencom.2020.11.019



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