Synthesis and biological activity of thiazole–carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian Polycarpa aurata

Based on bis(2-amino-4-phenyl-5-thiazolyl) disulfides, thiazole analogues of polycarpine, a cytotoxic alkaloid from the ascidian Polycarpa aurata, a wide range of thiazole–carbohydrate conjugates based on D-glucose and D-xylose has been obtained. Antitumor and antimicrobial activity for the synthesized compounds has been studied.