G. V. Pazynina, S. V. Tsygankova, I. M. Ryzhov, N. V. Shilova, S. M. Polyakova, A. S. Paramonov, A. A. Formanovsky, N. V. Bovin, “Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies”, Mendeleev Commun., 29:3 (2019), 254

Communications

Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies

G. V. Pazynina, S. V. Tsygankova, I. M. Ryzhov, N. V. Shilova, S. M. Polyakova, A. S. Paramonov, A. A. Formanovsky, N. V. Bovin

M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Аннотация: We have synthesized GalNGcα1-3GalNAcα disaccharide, a glycoloyl analogue of GalNAcα1-3GalNAcα known as the core 5 motif of mucin-type glycoproteins, and investigated how this structural variation affects the interaction with human natural antibodies. In contrast to the case of the Neu5NGc/Neu5NAc pair, the additional glycoloyl OH group in GalNGcα1-3GalNAcα markedly reduced the antigenicity of the GalNGcα moiety.

Язык публикации: английский

DOI: 10.1016/j.mencom.2019.05.004

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		Supplementary_data_1.pdf	348.7 Kb