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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2019, том 29, выпуск 4, страницы 375–377 (Mi mendc1527)

Эта публикация цитируется в 13 статьях

Communications

Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers

A. T. Lea, V. T. Trana, H. H. Truongb, L. M. Nguyenac, D. M. Luonga, T. T. Doa, D. T. Nguyena, N. T. Daoa, D. T. Lea, A. T. Soldatenkovb, V. N. Khrustalevbd

a Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
b Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
c Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Vietnam
d National Research Centre 'Kurchatov Institute', Moscow, Russian Federation


Аннотация: For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was studied by X-ray diffraction. Four crown compounds were evaluated in vitro for cytotoxic activity against 5 human cancer cell lines.

Язык публикации: английский

DOI: 10.1016/j.mencom.2019.07.004



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