E. I. Seleznev, E. Yu. Yamansarov, E. V. Lopatukhina, A. V. Lopuhov, D. A. Skvortsov, S. A. Evteev, E. T. Yamansarova, A. Yu. Adelgareeva, N. L. Klyachko, E. K. Beloglazkina, Ya. A. Ivanenkov, A. G. Majouga, “Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates”, Mendeleev Commun., 29:5 (2019), 526

Эта публикация цитируется в 1 статье

Communications

Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates

E. I. Seleznev^a, E. Yu. Yamansarov^a, E. V. Lopatukhina^a, A. V. Lopuhov^a, D. A. Skvortsov^a, S. A. Evteev^a, E. T. Yamansarova^b, A. Yu. Adelgareeva^b, N. L. Klyachko^ac, E. K. Beloglazkina^a, Ya. A. Ivanenkov^de, A. G. Majouga^afg

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Department of Chemistry, Bashkir State University, Ufa, Russian Federation
^c Skolkovo Institute of Science and Technology, Moscow, Russian Federation
^d Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation
^e Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Region, Russian Federation
^f D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^g National University of Science and Technology 'MISIS', Moscow, Russian Federation

Аннотация: New allobetulin conjugates were obtained through its O-esterification with hex-5-ynoic acid followed by [3+2]-cycloaddition with three azido derivatives of N-acetyl-d-galactosamine. The conjugates are non-toxic in micromolar range against hepatocellular carcinoma cell lines and have a high affinity towards the HO asialoglycoprotein receptor of hepatocytes based on molecular docking and surface plasmon resonance data.

Язык публикации: английский

DOI: 10.1016/j.mencom.2019.09.016

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