M. P. Paramonova, A. A. Ozerov, A. O. Chizhov, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication”, Mendeleev Commun., 29:6 (2019), 638

Эта публикация цитируется в 7 статьях

Communications

Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication

M. P. Paramonova^a, A. A. Ozerov^a, A. O. Chizhov^b, R. Snoeck^c, G. Andrei^c, A. L. Khandazhinskaya^d, M. S. Novikov^a

^a Volgograd State Medical University, Volgograd, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Rega Institute for Medical Research, Leuven, Belgium
^d V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation

Аннотация: A series of 1-[(bromophenoxy)alkyl]uracil–coumarin conjugates has been obtained through the preparation of starting 1-[(bromophenoxy)alkyl]uracil derivatives, followed by their treatment with 7-(ω-bromoalkoxy)-4-methyl-2H-chromen-2-ones. Two of the synthesized uracil–coumarin conjugates demonstrated a pronounced inhibitory activity against HCMV and VZV replication in vitro.

Язык публикации: английский

DOI: 10.1016/j.mencom.2019.11.010

	*Дополнительные материалы:*
		Supplementary_data_1.pdf	1.9 Mb