N. S. Rukk, L. G. Kuz'mina, G. A. Davydova, G. A. Buzanov, V. M. Retivov, S. K. Belus, E. I. Kozhukhova, A. E. Barmashov, A. A. Khrulev, M. A. Simonova, V. N. Krasnoperova, “Synthesis, structure and cytotoxicity of a zinc(II) bromide complex with caffeine”, Mendeleev Commun., 29:6 (2019), 640

Эта публикация цитируется в 8 статьях

Communications

Synthesis, structure and cytotoxicity of a zinc(II) bromide complex with caffeine

N. S. Rukk^a, L. G. Kuz'mina^b, G. A. Davydova^c, G. A. Buzanov^b, V. M. Retivov^d, S. K. Belus^d, E. I. Kozhukhova^d, A. E. Barmashov^e, A. A. Khrulev^a, M. A. Simonova^c, V. N. Krasnoperova^a

^a M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
^b N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Institute of Theoretical and Experimental Biophysics of RAS, Pushchino, Moscow region, Russian Federation
^d Institute of Chemical Reagents and High Purity Chemical Substances, National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
^e N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation

Аннотация: The synthesis and structure of a zinc(II) bromide complex with caffeine (caf), [Zn(caf)(H2O)Br2], are described in comparison with [Zn(caf)(H₂O)X₂] (X=Cl, I) complexes. Data on the cytotoxicity of [Zn(caf)(H₂O)X₂] (X=Cl, Br, I) towards human tumor cell lines are presented. The bromo complex has some advantages over chloro and iodo complexes for cytotoxicity on MCF-7 breast cancer cell line, and it is comparable to the chloro complex in cytotoxicity for Jurkat human T cell leukemia.

Язык публикации: английский

DOI: 10.1016/j.mencom.2019.11.011

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