K. N. Sedenkova, E. B. Averina, A. A. Nazarova, Yu. K. Grishin, D. S. Karlov, V. L. Zamoyski, V. V. Grigoriev, T. S. Kuznetsova, V. A. Palyulin, “The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold”, Mendeleev Commun., 28:4 (2018), 423

Эта публикация цитируется в 14 статьях

Communications

The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold

K. N. Sedenkova^ab, E. B. Averina^ab, A. A. Nazarova^a, Yu. K. Grishin^a, D. S. Karlov^ab, V. L. Zamoyski^b, V. V. Grigoriev^ab, T. S. Kuznetsova^a, V. A. Palyulin^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Аннотация: A convenient approach to novel symmetric bispyrimidine diamines comprises S_NAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the kainateinduced currents in Purkinje neurons and showed negative modulating effect.

Язык публикации: английский

DOI: 10.1016/j.mencom.2018.07.028

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