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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2025, том 35, выпуск 1, страницы 54–56 (Mi mendc1876)

Communications

Structure–activity relationships of key bioantioxidants in reactions with radicals in DPPH, AAPH, and Hb–H2O2 systems

V. A. Volkova, N. N. Sazhinaa, M. V. Voronkova, E. N. Kuleshovab

a N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation
b D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation


Аннотация: A comparative study of three systems based on various free radicals (AAPH azo initiator, hemoglobin–hydrogen peroxide, and DPPH) was performed by examining the kinetic and analytical properties of several significant bioantioxidants treated with these radicals. Common trends in structure–activity relationships for all three methods were shown. The measured data suggest a possibility of extrapolating the results obtained from one of the three methods to another when analyzing different chemical and biological objects.

Ключевые слова: antioxidants, free radicals, chemiluminescence, luminol, DPPH, uric acid, ascorbic acid, gallic acid, glutathione, mexidol.

Поступила в редакцию: 15.04.2024
Принята в печать: 03.09.2024

Язык публикации: английский

DOI: 10.71267/mencom.7466



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