RUS  ENG
Полная версия
ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2017, том 27, выпуск 1, страницы 82–84 (Mi mendc1903)

Эта публикация цитируется в 8 статьях

Communications

Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity

V. V. Abzianidzea, K. P. Bolshakovab, D. S. Prokofievaa, A. O. Berestetskiyc, V. A. Kuznetsova, Yu. G. Trishinb

a Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
b Saint-Petersburg State University of Industrial Technologies and Design, St. Petersburg, Russian Federation
c All-Russian Institute of Plant Protection, Federal Agency of Scientific Organizations, Pushkin, St. Petersburg, Russian Federation


Аннотация: The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of exocyclic C=C bond and N–OMe group in such compounds is suggested to be a factor in their antitumor activity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2017.01.026



© МИАН, 2025