V. V. Abzianidze, K. P. Bolshakova, D. S. Prokofieva, A. O. Berestetskiy, V. A. Kuznetsov, Yu. G. Trishin, “Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity”, Mendeleev Commun., 27:1 (2017), 82

Эта публикация цитируется в 8 статьях

Communications

Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity

V. V. Abzianidze^a, K. P. Bolshakova^b, D. S. Prokofieva^a, A. O. Berestetskiy^c, V. A. Kuznetsov^a, Yu. G. Trishin^b

^a Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
^b Saint-Petersburg State University of Industrial Technologies and Design, St. Petersburg, Russian Federation
^c All-Russian Institute of Plant Protection, Federal Agency of Scientific Organizations, Pushkin, St. Petersburg, Russian Federation

Аннотация: The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of exocyclic C=C bond and N–OMe group in such compounds is suggested to be a factor in their antitumor activity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2017.01.026

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