D. O. Prima, E. V. Vorontsova, A. G. Makarov, A. Yu. Makarov, I. Yu. Bagryanskaya, T. F. Mikhailovskaya, Yu. G. Slizhov, A. V. Zibarev, “Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis”, Mendeleev Commun., 27:5 (2017), 439

Эта публикация цитируется в 19 статьях

Communications

Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis

D. O. Prima^ab, E. V. Vorontsova^c, A. G. Makarov^a, A. Yu. Makarov^a, I. Yu. Bagryanskaya^ad, T. F. Mikhailovskaya^a, Yu. G. Slizhov^b, A. V. Zibarev^ab

^a N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^b Department of Chemistry, National Research Tomsk State University, Tomsk, Russian Federation
^c Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
^d Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russian Federation

Аннотация: The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.

Язык публикации: английский

DOI: 10.1016/j.mencom.2017.09.002

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